体内外方法揭示饮食策略能降低大米中镉的生物顶用

作者:anny    文章源泉:本站原创    法定人数:    更新时间:2020-6-5

Use of Dietary Components to Reduce the Bioaccessibility and Bioavailability of Cadmium in Rice

庄萍(通讯作者)全文下载:


ABSTRACT: Reducing Cd bioavailability in the systemic circulation is an alternative strategy to reduce Cd exposure. The influence
of 39 dietary components on Cd bioaccessibility in water or rice was determined using an in vitro gastrointestinal model, following
which an in vivo bioassay was used to determine the most effective components on Cd bioavailability in rice. The results showed that several components significantly reduced the solubility of Cd (10−98%) in the intestinal phase. Tannic acid, TiO2, zinc gluconate, CaCl2, and proanthocyanidins were the most effective in decreasing Cd bioaccessibility in rice, with reductions of 93−97, 54−61, 32−49, 24−32, and 11−14%, respectively. Upon adding the dietary components, the reduction rates of the Cd-relative bioavailability (Cd-RBA) were 20−58 and 10−31% in the kidneys and the liver, respectively. The results may have important implications for reducing health risks associated with Cd exposure via consumption of rice.


KEYWORDS: Cd-contaminated rice, dietary components, health risk, in vitro digestion model, mouse animal model


全文下载:/UploadFiles/file/202006/2020060516254673.pdf


发表于:J. Agric. Food Chem. 2020, 68, 4166−4175

 

文章下载:anny    责任编辑:anny 

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